Behind the smile: cell biology and disease mechanisms of Giardia species

被引：266

作者：

Ankarklev, Johan ^{[1
]}

Jerlstrom-Hultqvist, Jon ^{[1
]}

Ringqvist, Emma ^{[1
]}

Troell, Karin ^{[1
]}

Svard, Staffan G. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Cell & Mol Biol, Biomed Ctr, SE-75124 Uppsala, Sweden

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 06期

基金：

瑞典研究理事会;

关键词：

EPITHELIAL BARRIER FUNCTION; EARLY DIVERGING EUKARYOTE; LAMBLIA CYST WALL; ANTIGENIC VARIATION; TRANSCRIPTIONAL ACTIVATION; NUCLEI; EPIGENETIC MECHANISMS; PROVIDES EVIDENCE; SURFACE PROTEIN; MEIOTIC GENES;

D O I：

10.1038/nrmicro2317

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal stool. Nowadays, although G. intestinalis is recognized as a major worldwide contributor to diarrhoeal disease in humans and other mammals, the disease mechanisms are still poorly understood. Owing to its reduced complexity and proposed early evolutionary divergence, G. intestinalis is used as a model eukaryotic system for studying many basic cellular processes. In this Review we discuss recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis.

引用

页码：413 / 422

页数：10

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