Exclusion of repetitive DNA elements from gnathostome Hox clusters

被引：30

作者：

Fried, C

Prohaska, SJ

Stadler, PF

机构：

[1] Univ Leipzig, Dept Comp Sci, Bioinformat Grp, D-04103 Leipzig, Germany

[2] Univ Vienna, Inst Theoret Chem & Mol Strukt Biol, A-1090 Vienna, Austria

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION | 2004年 / 302B卷 / 02期

关键词：

D O I：

10.1002/jez.b.20007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Despite their homology and analogous function, the Hox gene clusters of vertebrates and invertebrates are subject to different constraints on their structural organization. This is demonstrated by a drastically different distribution of repetitive DNA elements in the Hox cluster regions. While gnathostomes have a strong tendency to exclude repetitive DNA elements from the inside of their Hox clusters, no such trend can be detected in the Hox gene clusters of protostomes. Repeats "invade" the gnathostome Hox clusters from the 5' and 3' ends while the core of the clusters remains virtually free of repetitive DNA. This invasion appears to be correlated with relaxed constraints associated with gene loss after cluster duplications. J. Exp. Zool. (Mol. Dev. Evol.) 302B:165-173, 2004. (C) 2004 Wiley-Liss, Inc.

引用

页码：165 / 173

页数：9

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