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The blood brain barrier in Alzheimer's disease

被引：81
作者：
Chakraborty, A. [1 ]
de Wit, N. M. [1 ]
van der Flier, W. M. [2 ,3 ,4 ]
de Vries, H. E. [1 ]
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Blood Brain Barrier Res Grp, Neurosci Campus Amsterdam,POB 7057, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Neurosci Campus Amsterdam, Amsterdam, Netherlands
来源：
VASCULAR PHARMACOLOGY | 2017年 / 89卷
关键词：
Alzheimer's disease; blood-brain barrier; vascular disorders; VASCULAR COGNITIVE IMPAIRMENT; CEREBRAL AMYLOID ANGIOPATHY; TIGHT JUNCTION PERMEABILITY; NEUROVASCULAR DYSFUNCTION; ENDOTHELIAL-CELLS; NEURODEGENERATIVE DISEASE; MITOCHONDRIAL DYSFUNCTION; CAROTID ATHEROSCLEROSIS; CEREBROVASCULAR-DISEASE; DIABETES-MELLITUS;
D O I：
10.1016/j.vph.2016.11.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people worldwide. One of the prominent causative factors of AD pathogenesis is cerebral vascular dysfunction, which results in diminished cerebral perfusion. Moreover, due to the loss of the protective function of the blood-brain barrier (BBB), impaired clearance of excess neurotoxic amyloid beta (A beta) occurs, causing vascular perturbation and diminished cognitive functioning. The relationship between the prevalence of AD and vascular risk factors is complex and not fully understood. In this review we illustrate the vascular risk factors, their effects on BBB function and their contributions to the onset of AD. Additionally, we discuss the underlying factors that may lead to altered neurovascular function and/or cerebral hypoperfusion in AD. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：12 / 18
页数：7
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