Antigen-dependent B-cell development

被引：94

作者：

Cariappa, A

Pillai, S ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[2] Harvard Med Sch, Charlestown, MA 02129 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(02)00328-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is growing evidence that the development of naive B cells depends on the interaction of self antigens with the BCR. A view that has emerged over the past year is that BCR signal output contributes in a large part to the developmental fate of peripheral B cells. Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype.

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页码：241 / 249

页数：9

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