Endocytosis and intracellular transport of ricin: recent discoveries

被引：63

作者：

Sandvig, K ^{[1
]}

van Deurs, B

机构：

[1] Norwegian Radium Hosp, Inst Canc Res, Oslo, Norway

[2] Univ Copenhagen, Panum Inst, Dept Med Anat, Struct Cell Biol Unit, DK-2200 Copenhagen, Denmark

来源：

FEBS LETTERS | 1999年 / 452卷 / 1-2期

关键词：

ricin; endocytosis; endosome; Golgi apparatus; endoplasmic reticulum;

D O I：

10.1016/S0014-5793(99)00529-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The plant toxin ricin has proven valuable as a membrane marker in studies of endocytosis as well as studies of different intracellular transport steps. The toxin, which consists of two polypeptide chains, binds by one chain (the B-chain) to both glycolipids and glycoproteins with terminal galactose at the cell surface, The other chain (the A-chain) enters the cytosol and inhibits protein synthesis enzymatically. After binding the toxin is endocytosed by different mechanisms, and it is transported via endosomes to the Golgi apparatus and the endoplasmic reticulum before translocation of the A-chain to the cytosol, The different transport steps have been analyzed by studying trafficking of ricin as well as modified ricin molecules, (C) 1999 Federation of European Biochemical Societies.

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页码：67 / 70

页数：4

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