Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis

被引：56

作者：

Amalakuhan, Bravein ^{[1
]}

Habib, Sheila A. ^{[1
]}

Mangat, Mandeep ^{[1
]}

Reyes, Luis F. ^{[1
,2
]}

Rodriguez, Alejandro H. ^{[6
,7
]}

Hinojosa, Cecilia A. ^{[1
]}

Soni, Nilam J. ^{[1
,2
]}

Gilley, Ryan P. ^{[1
]}

Bustamante, Carlos A. ^{[3
]}

Anzueto, Antonio ^{[1
,2
,9
]}

Levine, Stephanie M. ^{[1
,2
]}

Peters, Jay I. ^{[1
,2
]}

Aliberti, Stefano ^{[4
]}

Sibila, Oriol ^{[5
]}

Chalmers, James D. ^{[8
]}

Torres, Antoni

Waterer, Grant W. ^{[10
]}

Martin-Loeches, Ignacio ^{[11
]}

Bordon, Jose ^{[12
]}

Blanquer, Jose ^{[13
]}

Sanz, Francisco ^{[14
]}

Marcos, Pedro J. ^{[15
]}

Rello, Jordi ^{[16
]}

Ramirez, Julio ^{[17
]}

Sole-Violan, Jordi ^{[18
]}

Luna, Carlos M. ^{[19
]}

Feldman, Charles ^{[20
,21
]}

Witzenrath, Martin ^{[22
,23
]}

Wunderink, Richard G. ^{[24
]}

Stolz, Daiana ^{[25
]}

Wiemken, Tim L. ^{[17
]}

Shindo, Yuichiro ^{[26
,27
]}

Dela Cruz, Charles S. ^{[28
]}

Orihuela, Carlos J. ^{[1
,29
]}

Restrepo, Marcos I. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[2] South Texas Vet Hlth Care Syst, San Antonio, TX USA

[3] Camino Dist Univ Adelita Char, Barranquilla, Colombia

[4] Univ Milano Bicocca, Clin Pneumol, Monza, Italy

[5] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Med, Serv Pneumol, Barcelona, Spain

[6] Joan XXIII Univ Hosp, Crit Care Dept, Tarragona, Spain

[7] CIBERES, Pere Virgili Hlth Inst, Tarragona, Spain

[8] Univ Dundee, Dundee, Scotland

[9] Univ Barcelona, Hosp Clin, Serv Pneumol, Barcelona, Spain

[10] Univ Western Australia, Royal Perth Hosp Unit, Sch Med & Pharmacol, Perth, WA, Australia

[11] St James Hosp, Trinity Ctr Hlth Sci, CIBERES, Dublin, Ireland

[12] Providence Hosp, Infect Dis Sect, Dept Med, Washington, DC USA

[13] Hosp Clin Univ, Unidad Cuidados Intens Resp, Valencia, Spain

[14] Consorci Hosp Gen Univ Valencia, Dept Pulmonol, Valencia, Spain

[15] Univ Coruna UDC, CHUAC, Inst Invest Biomed A Coruna INIBIC, Serv Neumol, La Coruna, Spain

[16] Hosp Univ Vall dHebron, Crit Care Dept, CIBERES, Barcelona, Spain

[17] Univ Louisville, Div Infect Dis, Louisville, KY 40292 USA

[18] Hosp Univ Dr Negrin, Intens Care Unit, CIBERES, Las Palmas Gran Canaria, Spain

[19] Univ Buenos Aires, Div Pulmonol, Hosp Clin, Div Pulm Med,Dept Med, Buenos Aires, DF, Argentina

[20] Charlotte Maxeke Johannesburg Acad Hosp, Dept Internal Med, Johannesburg, South Africa

[21] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa

[22] Charite Univ Med Berlin, Dept Infect Dis & Pulm Med, Berlin, Germany

[23] SFB TR84 Innate Immun Lung, Berlin, Germany

[24] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Feinberg Sch Med, Chicago, IL 60611 USA

[25] Univ Basel Hosp, Clin Pulm Med & Resp Cell Res, Basel, Switzerland

[26] Nagoya Univ, Grad Sch Med, Inst Adv Res, Nagoya, Aichi, Japan

[27] Nagoya Univ, Grad Sch Med, Dept Resp Med, Nagoya, Aichi, Japan

[28] Yale Univ, Sch Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT USA

[29] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

CYTOKINE | 2016年 / 88卷

关键词：

Biomarkers; Sepsis; Shock; Mortality; Multiple organ failure; Intracellular Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor; GROWTH-FACTOR; PATHOGENESIS; DYSFUNCTION; ACTIVATION; ICAM-1; DEFINITIONS; BIOMARKERS; MORTALITY; SELECTIN; VCAM-1;

D O I：

10.1016/j.cyto.2016.08.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Objective: To determine if serum levels of endothelial adhesion molecules were associated with the development of multiple organ failure (MOF) and in-hospital mortality in adult patients with severe sepsis. Design: This study was a secondary data analysis of a prospective cohort study. Setting: Patients were admitted to two tertiary intensive care units in San Antonio, TX, between 2007 and 2012. Patients: Patients with severe sepsis at the time of intensive care unit (ICU) admission were enrolled. Inclusion criteria were consistent with previously published criteria for severe sepsis or septic shock in adults. Exclusion criteria included immunosuppressive medications or conditions. Interventions: None. Measurements: Baseline serum levels of the following endothelial cell adhesion molecules were measured within the first 72 h of ICU admission: Intracellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Vascular Endothelial Growth Factor (VEGF). The primary and secondary outcomes were development of MOF ( organ dysfunction) and in-hospital mortality, respectively. Main results: Forty-eight patients were enrolled in this study, of which 29 (60%) developed MOF. Patients that developed MOF had higher levels of VCAM-1 (p = 0.01) and ICAM-1 (p = 0.01), but not VEGF (p = 0.70) compared with patients without MOF (single organ failure only). The area under the curve (AUC) to predict MOF according to VCAM-1, ICAM-1 and VEGF was 0.71, 0.73, and 0.54, respectively. Only increased VCAM-1 levels were associated with in-hospital mortality (p = 0.03). These associations were maintained even after adjusting for APACHE and SOFA scores using logistic regression. Conclusions: High levels of serum ICAM-1 was associated with the development of MOF. High levels of VCAM-1 was associated with both MOF and in-hospital mortality. Published by Elsevier Ltd.

引用

页码：267 / 273

页数：7

共 25 条

[1]

DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].