A Review of Natural and Modified Betulinic, Ursolic and Echinocystic Acid Derivatives as Potential Antitumor and Anti-HIV Agents

被引：93

作者：

Baglin, I. ^{[1
]}

Mitaine-Offer, A. -C. ^{[1
]}

Nour, M. ^{[1
]}

Tan, K. ^{[1
]}

Cave, C. ^{[1
]}

Lacaille-Dubois, M. -A. ^{[1
]}

机构：

[1] Univ Bourgogne, Fac Pharm, Unite MIB, JE 2244, F-21079 Dijon, France

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 06期

关键词：

D O I：

10.2174/1389557033487917

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this review is to update current knownledge on the betulinic, ursolic and echinocystic acids and their natural and semisynthetic analogs, focussing on their cytotoxic and anti-HIV activities. Then, the last results of the authors' team on unusual semisynthetic derivatives of these triterpenoids will be presented in order to establish structure/activity relationships.

引用

页码：525 / 539

页数：15

共 94 条

[11] GLUCOSIDATION OF OLEANOLIC AND URSOLIC ACIDSUNDER PHASE-TRANSFER CATALYSIS [J].

CHERITI, A ;

BALANSARD, G .

NATURAL PRODUCT LETTERS, 1995, 7 (01) :47-50

[12] Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells [J].

Choi, BM ;

Park, R ;

Pae, HO ;

Yoo, JC ;

Kim, YC ;

Jun, CD ;

Jung, BH ;

Oh, GS ;

So, HS ;

Kim, YM ;

Chung, HT .

PHARMACOLOGY & TOXICOLOGY, 2000, 86 (02) :53-58

[13]

Choi YH, 2000, INT J ONCOL, V17, P565

[14] Effect of betulinic acid on intracellular-free Ca2+ levels in Madin Darby canine kidney cells [J].

Chou, KJ ;

Fang, HC ;

Chung, HM ;

Cheng, JS ;

Lee, KC ;

Tseng, LL ;

Tang, KY ;

Jan, CR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 408 (02) :99-106

[15]

ElSaady D, 1996, ANTICANCER RES, V16, P481

[16] EFFECTS OF URSOLIC ACID AND ITS ANALOGS ON SOYBEAN 15-LIPOXYGENASE ACTIVITY AND THE PROLIFERATION RATE OF A HUMAN GASTRIC TUMOR-CELL LINE [J].

ESSAADY, D ;

NAJID, A ;

SIMON, A ;

DENIZOT, Y ;

CHULIA, AJ ;

DELAGE, C .

MEDIATORS OF INFLAMMATION, 1994, 3 (03) :181-184

[17] Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest [J].

Essaady, D ;

Simon, A ;

Ollier, M ;

Maurizis, JC ;

Chulia, AJ ;

Delage, C .

CANCER LETTERS, 1996, 106 (02) :193-197

[18] Betulinic acid derivatives: A new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action [J].

Evers, M ;

Poujade, C ;

Soler, F ;

Ribeill, Y ;

James, C ;

Lelievre, Y ;

Gueguen, JC ;

Reisdorf, D ;

Morize, I ;

Pauwels, R ;

DeClercq, E ;

Henin, Y ;

Bousseau, A ;

Mayaux, JF ;

LePecq, JB ;

Dereu, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (05) :1056-1068

[19]

Feng XZ, 2001, PHARMAZIE, V56, P663

[20] ANTI-AIDS AGENTS .11. BETULINIC ACID AND PLATANIC ACID AS ANTI-HIV PRINCIPLES FROM SYZIGIUM-CLAVIFLORUM, AND THE ANTI-HIV ACTIVITY OF STRUCTURALLY RELATED TRITERPENOIDS [J].

FUJIOKA, T ;

KASHIWADA, Y ;

KILKUSKIE, RE ;

COSENTINO, LM ;

BALLAS, LM ;

JIANG, JB ;

JANZEN, WP ;

CHEN, IS ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (02) :243-247

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