A Review of Natural and Modified Betulinic, Ursolic and Echinocystic Acid Derivatives as Potential Antitumor and Anti-HIV Agents

被引：93

作者：

Baglin, I. ^{[1
]}

Mitaine-Offer, A. -C. ^{[1
]}

Nour, M. ^{[1
]}

Tan, K. ^{[1
]}

Cave, C. ^{[1
]}

Lacaille-Dubois, M. -A. ^{[1
]}

机构：

[1] Univ Bourgogne, Fac Pharm, Unite MIB, JE 2244, F-21079 Dijon, France

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 06期

关键词：

D O I：

10.2174/1389557033487917

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this review is to update current knownledge on the betulinic, ursolic and echinocystic acids and their natural and semisynthetic analogs, focussing on their cytotoxic and anti-HIV activities. Then, the last results of the authors' team on unusual semisynthetic derivatives of these triterpenoids will be presented in order to establish structure/activity relationships.

引用

页码：525 / 539

页数：15

共 94 条

[21]

Fulda S, 1999, INT J CANCER, V82, P435, DOI 10.1002/(SICI)1097-0215(19990730)82:3<435::AID-IJC18>3.0.CO

[22]

2-1

[23]

Fulda S, 1997, CANCER RES, V57, P4956

[24]

Fulda S, 1998, CANCER RES, V58, P4453

[25] Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid [J].

Fulda, S ;

Scaffidi, C ;

Susin, SA ;

Krammer, PH ;

Kroemer, G ;

Peter, ME ;

Debatin, KM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (51) :33942-33948

[26]

Fulda S, 2000, MED PEDIATR ONCOL, V35, P616, DOI 10.1002/1096-911X(20001201)35:6<616::AID-MPO27>3.0.CO

[27]

2-N

[28] Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors [J].

Fulda, S ;

Jeremias, I ;

Pietsch, T ;

Debatin, KM .

KLINISCHE PADIATRIE, 1999, 211 (04) :319-322

[29] A new major triterpene saponin from the roots of Cucurbita foetidissima [J].

Gaidi, G ;

Marouf, A ;

Hanquet, B ;

Bauer, R ;

Correia, M ;

Chauffert, B ;

Lacaille-Dubois, MA .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01) :122-124

[30] Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina [J].

Guo, SJ ;

Kenne, L .

PHYTOCHEMISTRY, 2000, 55 (05) :419-428

← 1 2 3 4 5 6 7 8 9 10 →