Obesity but not overweight increases the incidence and mortality of leukemia in adults: A meta-analysis of prospective cohort studies

被引：105

作者：

Castillo, Jorge J. ^{[1
]}

Reagan, John L. ^{[1
]}

Ingham, Randall R. ^{[2
]}

Furman, Michael ^{[2
]}

Dalia, Samir ^{[2
]}

Merhi, Basma ^{[2
]}

Nemr, Saed ^{[2
]}

Zarrabi, Ali ^{[3
]}

Mitri, Joanna ^{[4
]}

机构：

[1] Brown Univ, Miriam Hosp, Div Hematol Oncol, Warren Alpert Med Sch, Providence, RI 02906 USA

[2] Brown Univ, Miriam Hosp, Dept Med, Warren Alpert Med Sch, Providence, RI 02906 USA

[3] Brown Univ, Warren Alpert Med Sch, Providence, RI 02906 USA

[4] Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA USA

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 07期

关键词：

Obesity; Body mass index; Leukemia; Meta-analysis; Incidence; Mortality; Risk; BODY-MASS INDEX; BONE-MARROW MICROENVIRONMENT; NON-HODGKINS-LYMPHOMA; CANCER-RISK; MULTIPLE-MYELOMA; NATIONAL-HEALTH; POOLED ANALYSIS; MALIGNANCIES; MEN; WEIGHT;

D O I：

10.1016/j.leukres.2011.12.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The main objectives of the present meta-analysis of prospective cohort studies were to evaluate the role of obesity on the incidence and mortality of leukemia in adults. Obesity was associated with a relative risk (RR) of 1.26 (95% CI 1.17-1.37; p < 0.001) for leukemia incidence and 1.29 (95% CI 1.11-1.49; p = 0.001) for mortality. Obesity was also associated with an increased incidence of acute myeloid leukemia (RR 1.53, 95% CI 1.26-1.85; p < 0.001), chronic lymphocytic leukemia (RR 1.17, 95% CI 1.08-1.27; p < 0.001), chronic myeloid leukemia (RR 1.16, 95% CI 1.04-1.30; p = 0.007) and acute lymphoblastic leukemia (RR 1.62, 95% CI 1.12-2.32; p = 0.009). The risk of incidence and mortality of leukemia in adults was consistently higher in obese men. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：868 / 875

页数：8

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