Regulatory T Cell Induction, Migration, and Function in Transplantation

被引：45

作者：

Burrell, Bryna E. ^{[2
]}

Nakayama, Yumi ^{[2
]}

Xu, Jiangnan ^{[2
]}

Brinkman, C. Colin ^{[2
]}

Bromberg, Jonathan S. ^{[1
,2
,3
]}

机构：

[1] Univ Maryland, Sch Med, Ctr Vasc & Inflammatory Dis, Transplant Off, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

JOURNAL OF IMMUNOLOGY | 2012年 / 189卷 / 10期

基金：

美国国家卫生研究院;

关键词：

TOLEROGENIC DENDRITIC CELLS; DELAYED-TYPE HYPERSENSITIVITY; GROWTH-FACTOR-BETA; CUTTING EDGE; ALLOGRAFT TOLERANCE; OPERATIONAL TOLERANCE; MEDIATE TOLERANCE; IMMUNE REGULATION; GRAFT-REJECTION; RABBIT ATG;

D O I：

10.4049/jimmunol.1202027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Treg) are important in maintaining immune homeostasis and in regulating a variety of immune responses, making them attractive targets for modulating immune-related diseases. Success in using induction or transfer of Treg in mice to mediate transplant tolerance suggests Treg-based therapies as mechanisms of long-term drug-free transplant tolerance in human patients. Although more work is needed, critical analyses suggest that key factors in Treg induction, migration, and function are important areas to concentrate investigative efforts and therapeutic development. Elucidation of basic biology will aid in translating data gleaned from mice to humans so that Treg therapies become a reality for patients. The Journal of Immunology, 2012, 189: 4705-4711.

引用

页码：4705 / 4711

页数：7

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