Discovery of CP-199,330 and CP-199,331:: Two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity

被引：14

作者：

Chambers, RJ ^{[1
]}

Marfat, A ^{[1
]}

Antognoli, GW ^{[1
]}

Cheng, JB ^{[1
]}

Damon, DB ^{[1
]}

Kuperman, AV ^{[1
]}

Liston, TC ^{[1
]}

Mebus, C ^{[1
]}

Pillar, JS ^{[1
]}

Shirley, JT ^{[1
]}

Watson, JW ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(99)00461-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

CP-199,330 (3) and CP-199,331 (4) are cysLT(1) receptor antagonists that are equipotent to marketed cysLT(1) receptor antagonists zafirlukast and pranlukast, show good pharmacokinetics in rats and monkeys, and are devoid of liver toxicity in monkeys as seen in CP-85,958 (1). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2773 / 2778

页数：6

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