CSF-1/CSF-1R targeting agents in clinical development for cancer therapy

被引：112

作者：

Ries, Carola H. ^{[1
]}

Hoves, Sabine ^{[1
]}

Cannarile, Michael A. ^{[1
]}

Ruettinger, Dominik ^{[1
]}

机构：

[1] Roche Innovat Ctr Penzberg, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany

来源：

CURRENT OPINION IN PHARMACOLOGY | 2015年 / 23卷

关键词：

TUMOR-ASSOCIATED MACROPHAGES; INFILTRATING MYELOID CELLS; KINASE INHIBITOR; GENETIC PROGRAMS; C-FMS; IMPROVES; POLARIZATION; EFFICACY; ANTIBODY; REVEALS;

D O I：

10.1016/j.coph.2015.05.008

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Macrophage infiltration has been identified as an independent poor prognostic factor for several cancer entities. In mouse tumor models macrophages orchestrate various tumor-promoting processes. This observation sparked an interest to therapeutically target these plastic innate immune cells. To date, blockade of colony stimulating factor-1 or its receptor represents the only truly selective approach to manipulate macrophages in cancer patients. Here, we discuss the currently available information on efficacy and safety of various CSF-1/CSF-1R inhibitors in cancer patients and highlight potential combination partners emerging from preclinical studies while considering the differences between mouse and human macrophage biology.

引用

页码：45 / 51

页数：7

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