Biomarkers of acute kidney injury

被引：176

作者：

Edelstein, Charles L. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Div Renal Dis & Hypertens, Hlth Sci Ctr, Denver, CO 80262 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2008年 / 15卷 / 03期

关键词：

biomarkers; acute kidney injury; interleukin-18; neutrophil gelatinase-associated lipocalin; kidney injury molecule-1; cystatin C;

D O I：

10.1053/j.ackd.2008.04.003

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The diagnosis of acute kidney injury (AKI) is usually based on measurements of blood urea nitrogen. (BUN) and serum creatinine. BUN and serum creatinine are not very sensitive or specific for the diagnosis of AKI because they are affected by many renal and nonrenal factors that are independent of kidney injury or kidney function. Biomarkers of AKI that are made predominantly by the injured kidney have been discovered in preclinical studies. In clinical studies of patients with AKI, some of these biomarkers (eg, interleukin-18, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1) have been shown to increase in the urine before the increase in serum creatinine. These early biomarkers of AKI are being tested in different types of AKI and in larger clinical studies. Biomarkers of AKI may also predict long-term kidney outcomes and mortality. (C) 2008 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：222 / 234

页数：13

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