Design and fabrication of a hydrodynamic chromatography chip

被引:39
作者
Blom, MT
Chmela, E
Gardeniers, JGE
Tijssen, R
Elwenspoek, M
van den Berg, A
机构
[1] Univ Twente, MESA Res Inst, NL-7500 AE Enschede, Netherlands
[2] Univ Amsterdam, Dept Chem Engn, NL-1018 WV Amsterdam, Netherlands
关键词
hydrodynamic chromatography; chemical analysis; microfluidic chip;
D O I
10.1016/S0925-4005(01)00989-3
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A chromatography chip is presented in which the analysis is performed by polymer separation entirely based on geometry. Design and fabrication are discussed for a chip incorporating an injection structure and a separation channel. The injection is characterized by fluorescence measurements. Chromatographic performance was shown by separation of fluorescein and 26 nm fluorescent particles. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:111 / 116
页数:6
相关论文
共 17 条
[1]   Failure mechanisms of pressurized microchannels, model, and experiments [J].
Blom, MT ;
Tas, NR ;
Pandraud, G ;
Chmela, E ;
Gardeniers, JGE ;
Tijssen, R ;
Elwenspoek, M ;
van den Berg, A .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2001, 10 (01) :158-164
[2]  
DEBOER M, 2001, IN PRESS GUIDELINES
[3]   Electroosmosis- and pressure-driven chromatography in chips using continuous beds [J].
Ericson, C ;
Holm, J ;
Ericson, T ;
Hjertén, S .
ANALYTICAL CHEMISTRY, 2000, 72 (01) :81-87
[4]   Capillary electrochromatography of peptides in a microfabricated system [J].
He, B ;
Ji, JY ;
Regnier, FE .
JOURNAL OF CHROMATOGRAPHY A, 1999, 853 (1-2) :257-262
[5]   Fabrication of nanocolumns for liquid chromatography [J].
He, B ;
Tait, N ;
Regnier, F .
ANALYTICAL CHEMISTRY, 1998, 70 (18) :3790-3797
[6]   The black silicon method.: VIII.: A study of the performance of etching silicon using SF6/O2-based chemistry with cryogenical wafer cooling and a high density ICP source [J].
Jansen, H ;
de Boer, M ;
Wensink, H ;
Kloeck, B ;
Elwenspoek, M .
MICROELECTRONICS JOURNAL, 2001, 32 (09) :769-777
[7]   Liquid chromatography on-chip:: progression towards a μ-total analysis system [J].
McEnery, M ;
Tan, AM ;
Alderman, J ;
Patterson, J ;
O'Mathuna, SC ;
Glennon, JD .
ANALYST, 2000, 125 (01) :25-27
[8]  
OCVIRK G, 1995, ANAL METHOD INSTRUM, V2, P74
[9]  
ODLEY G, 1947, J APPL MECH, V14, P289
[10]   LOW-TEMPERATURE PYREX GLASS WAFER DIRECT BONDING [J].
PIGEON, F ;
BIASSE, B ;
ZUSSY, M .
ELECTRONICS LETTERS, 1995, 31 (10) :792-793