Vitamin D: Metabolism

被引：74

作者：

Christakos, Sylvia ^{[1
]}

Ajibade, Dare V. ^{[1
]}

Dhawan, Puneet ^{[1
]}

Fechner, Adam J. ^{[2
]}

Mady, Leila J. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USA

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Obstet & Gynecol & Womens Hlth, Newark, NJ 07103 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2012年 / 38卷 / 01期

关键词：

Vitamin D metabolites; Vitamin D hydroxylases; Vitamin D binding protein; FGF23; Kidney; Placenta; 25-HYDROXYVITAMIN D-3-1-ALPHA-HYDROXYLASE GENE; D-3 1-ALPHA-HYDROXYLASE GENE; DOMINANT HYPOPHOSPHATEMIC RICKETS; CHRONIC KIDNEY-DISEASE; D-DEFICIENCY RICKETS; D-BINDING PROTEIN; PARATHYROID-HORMONE; 1,25-DIHYDROXYVITAMIN D-3; PHYSIOLOGICAL-ROLE; D-RECEPTOR;

D O I：

10.1016/j.rdc.2012.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biologically active metabolite of vitamin D, 1,25(OH)(2)D-3, affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH)(2)D-3. The role of extrarenal 1 alpha(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.

引用

页码：1 / +

页数：12

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