Highly active iridium catalysts for the hydrogenation of ketones and aldehydes

被引：49

作者：

Chen, Xuanhua ^{[1
]}

Jia, Wenli ^{[1
]}

Guo, Rongwei ^{[1
]}

Graham, Todd W. ^{[1
]}

Gullons, Meredith A. ^{[1
]}

Abdur-Rashid, Kamaluddin ^{[1
]}

机构：

[1] Kanata Chem Technol Inc, MaRS Ctr, Toronto, ON M5G 1L7, Canada

来源：

DALTON TRANSACTIONS | 2009年 / 08期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; BASE-FREE CONDITIONS; STEREOSELECTIVE HYDROGENATION; ENANTIOSELECTIVE HYDROGENATION; RUTHENIUM(II) COMPLEXES; CARBONYL-COMPOUNDS; C=O HYDROGENATION; AROMATIC KETONES; HYDRIDE COMPLEX; LIGANDS;

D O I：

10.1039/b815501a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The pressure hydrogenation capabilities of the iridium pincer complexes IrH2Cl[((Pr2PC2H4)-Pr-i)(2)NH] (1) and IrH3[((Pr2PC2H4)-Pr-i)(2)NH] (2) are described and compared to related results obtained previously in transfer hydrogenation. Complex 1 was shown to act as a convenient air-stable entry point to the active catalyst 2, in the presence of base and hydrogen gas. The catalysts are active in a range of solvents, including CH2Cl2 and CHCl3, in contrast to related ruthenium systems. This class of iridium complexes is very effective for the direct hydrogenation of a wide range of carbonyl compounds including ketones, diketones, alpha,beta-unsaturated ketones and aldehydes. A catalytic cycle is proposed for this system which involves an ionic heterolytic bifunctional hydrogenation mechanism.

引用

页码：1407 / 1410

页数：4

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