Lignans and other constituents of the fruits of Euterpe oleracea (acai) with antioxidant and cytoprotective activities

被引:148
作者
Chin, Young-Won [1 ]
Chai, Hee-Byung [1 ]
Keller, William J. [2 ]
Kinghorn, A. Douglas [1 ]
机构
[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA
[2] Nat Sunshine Prod Inc, Spanish Fork, UT 84660 USA
关键词
Euterpe oleracea; lignans; benzenoid; phenylpropanoid; hydroxyl radical scavenging activity; 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity; cytoprotection;
D O I
10.1021/jf801792n
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Using a hydroxyl radical scavenging assay, bioactivity-guided fractionation of a methanol-soluble extract of the fruits of Euterpe oleracea (acai) led to the isolation of 22 compounds of previously known structure. Altogether, 14 of these isolates were found to be active in an in vitro hydroxyl radical scavenging assay and seven of these isolates in a 1, 1 -diphenyl-2-picrylhydrazyl radical scavenging assay. Dihydroconiferyl alcohol, (+)-lariciresinol, (+)-pinoresinol, (+)-syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types.
引用
收藏
页码:7759 / 7764
页数:6
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