A role in learning for SRF:: Deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context

被引:181
作者
Etkin, A
Alarcón, JM
Weisberg, SP
Touzani, K
Huang, YY
Nordheim, A
Kandel, ER
机构
[1] Columbia Univ, Ctr Med, Ctr Neurobiol & Behav, New York, NY 10032 USA
[2] Columbia Univ, Ctr Med, Kavli Inst Brain Sci, New York, NY 10032 USA
[3] Columbia Univ, Ctr Med, Div Mol Genet, New York, NY 10032 USA
[4] Columbia Univ, Ctr Med, Dept Pediat, New York, NY 10032 USA
[5] Columbia Univ, Ctr Med, Howard Hughes Med Inst, New York, NY 10032 USA
[6] CUNY, Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA
[7] Univ Tubingen, Abt Molekularbiol, Interfak Inst Zellbiol, Tubingen, Germany
关键词
D O I
10.1016/j.neuron.2006.03.013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Whereas significant insight exists as to how LTP-related changes can contribute to the formation of long-term memory, little is known about the role of hippocampal LTD-like changes in learning and memory storage. We describe a mouse lacking the transcription factor SRF in the adult forebrain. This mouse could not acquire a hippocampus-based immediate memory for a novel context even across a few minute timespan, which led to a profound but selective deficit in explicit spatial memory. These animals were also impaired in the induction of LTD, including LTD triggered by a cholinergic agonist. Moreover, genes regulating two processes essential for LTD-calcium release from intracellular stores and phosphatase activation-were abnormally expressed in knockouts. These findings suggest that for the hippocampus to form associative spatial memories through LTP-like processes, it must first undergo learning of the context per se through exploration and the learning of familiarity, which requires LTD-like processes.
引用
收藏
页码:127 / 143
页数:17
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