NK and MSCs Crosstalk: The Sense of Immunomodulation and Their Sensitivity

被引：61

作者：

Casado, Javier G. ^{[1
]}

Tarazona, R. ^{[2
]}

Sanchez-Margallo, F. M. ^{[1
]}

机构：

[1] Minimally Invas Surg Ctr Jesus Uson, Stem Cell Therapy Unit, Caceres 10071, Spain

[2] Univ Extremadura, Dept Physiol, Immunol Unit, Caceres, Spain

来源：

STEM CELL REVIEWS AND REPORTS | 2013年 / 9卷 / 02期

关键词：

NK cells; Mesenchymal stem cells; Immunomodulation; Innate Response; NK cell-mediated lysis; MESENCHYMAL STEM-CELLS; NATURAL-KILLER-CELLS; CYTOTOXIC T-LYMPHOCYTES; STROMAL CELLS; PROSTAGLANDIN E-2; INTERFERON-GAMMA; CD34(+) CELLS; IN-VIVO; INHIBIT; DIFFERENTIATION;

D O I：

10.1007/s12015-013-9430-y

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Several clinical trials are currently evaluating the safety and efficacy of mesenchymal stem cells (MSCs) in different diseases. The MSCs are guided by inflammatory mediators and specific interactions with immune cells occur, especially between MSCs and the cells of the innate immune system. At the present many of these interactions remain to be determined. This review summarizes the current knowledge in relation to the susceptibility of MSCs to NK cell mediated lysis as well as the immunomodulatory activity of MSCs and its control over NK cell function. Here we hypothesize that the inflammatory context will regulate the outcome of NK-MSC interactions.

引用

页码：184 / 189

页数：6

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