共 43 条
T-cell responses to the Mycobacterium tuberculosis-specific antigens in active tuberculosis patients at the beginning, during, and after antituberculosis treatment
被引:45
作者:

Dominguez, Jose
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

De Souza-Galvao, Malu
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Unidad Prevenc & Control TB Barcelona, Barcelona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Ruiz-Manzano, Juan
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Serv Pneumol, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Latorre, Irene
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Prat, Cristina
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Lacoma, Alicia
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Mila, Celia
论文数: 0 引用数: 0
h-index: 0
机构:
Unidad Prevenc & Control TB Barcelona, Barcelona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Angeles Jimenez, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Unidad Prevenc & Control TB Barcelona, Barcelona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Blanco, Silvia
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Maldonado, Jose
论文数: 0 引用数: 0
h-index: 0
机构:
Serv Clin Barcelona, Barcelona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Altet, Neus
论文数: 0 引用数: 0
h-index: 0
机构:
Unidad Prevenc & Control TB Barcelona, Barcelona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain

Ausina, Vicente
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
机构:
[1] Hosp Badalona Germans Trias & Pujol, Microbiol Serv, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
[2] Hosp Badalona Germans Trias & Pujol, Serv Pneumol, Fdn Inst Invest Ciencies Salut Germans Trias & Pu, Barcelona 08916, Spain
[3] Univ Autonoma Barcelona, E-08193 Barcelona, Spain
[4] Inst Salud Carlos III, Badalona, Spain
[5] Unidad Prevenc & Control TB Barcelona, Barcelona, Spain
[6] Serv Clin Barcelona, Barcelona, Spain
关键词:
Active tuberculosis;
Mycobacterium tuberculosis;
INTERFERON-GAMMA ASSAY;
LINKED IMMUNOSPOT ASSAY;
RELEASE ASSAYS;
IFN-GAMMA;
BLOOD-TESTS;
SKIN-TEST;
DIAGNOSIS;
INFECTION;
DISEASE;
ESAT-6;
D O I:
10.1016/j.diagmicrobio.2008.09.010
中图分类号:
R51 [传染病];
学科分类号:
100401 ;
摘要:
The objectives of the study were to assess the performance of the QuantiFERON-TB Gold In-Tube (QFN-G-IT) and the T-SPOT.TB tests in the immunodiagnosis of active tuberculosis (TB) in adult patients, and to Study the T-cell interferon gamma (IFN-gamma) responses during treatment and in patients who have recovered after curative treatment and self-healed TB patients. When only analyzing patients included at the beginning of treatment, the sensitivity was 83.3% for T-SPOT.TB and 69.4% for QFN-G-IT. In contrast, when evaluating patients during treatment, the sensitivity of the T-SPOT.TB and QFN-G-IT decreased to 69.8% and 48.8%, respectively. The response to the specific antigens increased after finishing the treatment compared with the values during the treatment. The T-SPOT.TB was more sensitive in diagnosing active TB than the QFN-G-IT. The IFN-gamma tests could be used as a complementary method in the diagnosis of active TB. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:43 / 51
页数:9
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Univ Autonoma Barcelona, Bellaterra, Spain
Inst Salud Carlos III, Badalona, Spain Hosp Univ Germans Trias & Pujol, Fdn Inst Ciencies Salut Germans Trias & Pujol, Microbiol Serv, Barcelona 08916, Spain
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Dosanjh, Davinder P. S.
论文数: 0 引用数: 0
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机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Resp Med, TB Immunol Grp, London W2 1PG, England

Hinks, Timothy S. C.
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Innes, John A.
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Deeks, Jonathan J.
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Pasvol, Geoffrey
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Hackforth, Sarah
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Varia, Hansa
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Millington, Kerry A.
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Gunatheesan, Rubamalar
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Guyot-Revol, Valerie
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Lalvani, Ajit
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Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Resp Med, TB Immunol Grp, London W2 1PG, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Resp Med, TB Immunol Grp, London W2 1PG, England