Chronic stress elevates telomerase activity in rats

被引：66

作者：

Beery, Annaliese K. ^{[1
]}

Lin, Jue ^{[3
,4
]}

Biddle, Joshua S. ^{[2
,5
]}

Francis, Darlene D. ^{[2
,5
]}

Blackburn, Elizabeth H. ^{[3
,4
]}

Epel, Elissa S. ^{[6
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

[2] Univ Calif Berkeley, Dept Publ Hlth, Berkeley, CA 94720 USA

[3] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94158 USA

[5] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[6] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

来源：

BIOLOGY LETTERS | 2012年 / 8卷 / 06期

关键词：

chronic stress; telomere; telomerase; ageing; resilience; OXIDATIVE STRESS; STEM-CELLS; LIFE-SPAN; HUMAN T; LENGTH; PERSPECTIVE; REDUCTION; DYNAMICS; BEHAVIOR; TISSUE;

D O I：

10.1098/rsbl.2012.0747

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The enzyme telomerase lengthens telomeres-protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-related physiological and behavioural outcomes. This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence.

引用

页码：1063 / 1066

页数：4

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