Optogenetics and Translational Medicine

被引：97

作者：

Chow, Brian Y. ^{[1
]}

Boyden, Edward S. ^{[2
,3
,4
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[3] MIT, Dept Brain & Cognit Sci, Media Lab, Cambridge, MA 02139 USA

[4] MIT, McGovern Inst, Cambridge, MA 02139 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2013年 / 5卷 / 177期

基金：

美国国家科学基金会;

关键词：

PROTEIN INTERACTIONS; VISUAL FUNCTION; ACTIVATION; EXPRESSION; INDUCTION; GLUCOSE; CELLS; MICE;

D O I：

10.1126/scitranslmed.3003101

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Optogenetic tools enable light-mediated control of cellular excitability and signaling in vivo. By manipulating biological processes, scientists can determine the roles played by these processes in intact biological systems, such as the brain. Such cellular-level control has greatly affected basic science. Here, we discuss how optogenetic tools might be translated into clinical impact through identification of new molecular and circuit-level targets and provide temporally precise interventions for defined biochemical or cellular events.

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