Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins

被引：124

作者：

Akbaba, Yusuf ^{[1
]}

Akincioglu, Akin ^{[1
]}

Gocer, Hulya ^{[1
,2
]}

Goksu, Suleyman ^{[1
]}

Gulcin, Ilhami ^{[1
]}

Supuran, Claudiu T. ^{[3
]}

机构：

[1] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey

[2] Ibrahim Cecen Univ Agri, Cent Researching Lab, Agri, Turkey

[3] Univ Florence, Chim Bioorgan Lab, Florence, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2014年 / 29卷 / 01期

关键词：

Aminoindane; aminotetralin; carbonic anhydrase; enzyme inhibition; sulfonamide; ERYTHROCYTE ISOZYMES I; VITRO; ACETAZOLAMIDE; PURIFICATION; DANTROLENE; MELATONIN; SERIES; ACID; QSAR;

D O I：

10.3109/14756366.2012.750311

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl) methane sulfonamide showed the most potent inhibitory effect against hCA I (K-i = 46 +/- 5.4 mu M, r(2) = 0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl) methanesulfonamide was found to have the best inhibitory effect against hCA II (K-i = 94 +/- 7.6 mu M, r(2) = 0.982).

引用

页码：35 / 42

页数：8

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