TALEN-mediated editing of the mouse Y chromosome

被引：87

作者：

Wang, Haoyi ^{[1
]}

Hu, Yueh-Chiang ^{[1
,2
]}

Markoulaki, Styliani ^{[1
]}

Welstead, G. Grant ^{[1
]}

Cheng, Albert W. ^{[1
,3
]}

Shivalila, Chikdu S. ^{[1
,4
]}

Pyntikova, Tatyana ^{[1
]}

Dadon, Daniel B. ^{[1
,4
]}

Voytas, Daniel F. ^{[5
]}

Bogdanove, Adam J. ^{[6
]}

Page, David C. ^{[1
,2
,4
]}

Jaenisch, Rudolf ^{[1
,4
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA USA

[3] MIT, Computat & Syst Biol Program, Cambridge, MA 02139 USA

[4] MIT, Dept Biol, Cambridge, MA USA

[5] Univ Minnesota, Dept Genet Cell Biol & Dev, St Paul, MN 55108 USA

[6] Cornell Univ, Dept Plant Pathol & Plant Microbe Biol, Ithaca, NY USA

来源：

NATURE BIOTECHNOLOGY | 2013年 / 31卷 / 06期

基金：

美国国家卫生研究院;

关键词：

GENE; MICE; SRY;

D O I：

10.1038/nbt.2595

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes-Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.

引用

页码：530 / 532

页数：3

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