Cellular senescence and organismal aging

被引：259

作者：

Jeyapalan, Jessie C. ^{[1
]}

Sedivy, John M. ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2008年 / 129卷 / 7-8期

关键词：

cellular senescence; aging; telomeres;

D O I：

10.1016/j.mad.2008.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Cellular senescence, first observed and defined using in vitro cell culture studies, is an irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging evidence suggests that cellular senescence acts as an in vivo tumor suppression mechanism by limiting aberrant proliferation. It has also been postulated that cellular senescence can occur independently of cancer and contribute to the physiological processes of normal organismal aging. Recent data have demonstrated the in vivo accumulation of senescent cells with advancing age. Some characteristics of senescent cells, such as the ability to modify their extracellular environment, could play a role in aging and age-related pathology. In this review, we examine current evidence that links cellular senescence and organismal aging. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：467 / 474

页数：8

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