Expanding the scope of Lewis acid catalysis in water:: Remarkable ligand acceleration of aqueous ytterbium triflate catalyzed Michael addition reactions

被引：35

作者：

Ding, R ^{[1
]}

Katebzadeh, K ^{[1
]}

Roman, L ^{[1
]}

Bergquist, KE ^{[1
]}

Lindström, UM ^{[1
]}

机构：

[1] Univ Lund, Dept Organ Chem, SE-22100 Lund, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 01期

关键词：

D O I：

10.1021/jo051540n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Significant rate acceleration of metal-catalyzed Michael addition reactions in water was observed upon addition of small, dibasic ligands. Ytterbium triflate and TMEDA was the most effective combination leading to a nearly 20-fold faster reaction than in the absence of ligand.

引用

页码：352 / 355

页数：4

共 17 条

[11] Lewis acid catalysts stable in water. Correlation between catalytic activity in water and hydrolysis constants and exchange rate constants for substitution of inner-sphere water ligands [J].