Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!

被引:241
作者
Fan, Yun [1 ]
Bergmann, Andreas [1 ,2 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Genes & Dev Grad Program, Houston, TX 77030 USA
关键词
D O I
10.1016/j.tcb.2008.08.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In multi-cellular organisms, activation of apoptosis can trigger compensatory proliferation in surrounding cells to maintain tissue homeostasis. Genetic studies in Drosophila have indicated that distinct mechanisms of compensatory proliferation are employed in apoptotic tissues of different developmental states. In proliferating eye and wing tissues, the initiator caspase Dronc coordinates cell death and compensatory proliferation through the Jun N-terminal kinase and p53. The mitogens Decapentaplegic and Wingless are induced in this process. By contrast, in differentiating eye tissues, the effector caspases DrICE and Dcp-1 activate the Hedgehog signaling pathway to induce compensatory proliferation. In this review, we summarize these findings and discuss how activation of apoptosis is linked to the process of compensatory proliferation. The developmental and pathological relevance of compensatory proliferation is also discussed.
引用
收藏
页码:467 / 473
页数:7
相关论文
共 66 条
[31]   Caspases in cell survival, proliferation and differentiation [J].
Lamkanfi, M. ;
Festjens, N. ;
Declercq, W. ;
Vanden Berghe, T. ;
Vandenabeele, P. .
CELL DEATH AND DIFFERENTIATION, 2007, 14 (01) :44-55
[32]  
Laundrie B, 2003, GENETICS, V165, P1881
[33]   MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation [J].
Lee, KK ;
Ohyama, T ;
Yajima, N ;
Tsubuki, S ;
Yonehara, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (22) :19276-19285
[34]   The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth nonautonomously [J].
Lee, Tom V. ;
Ding, Tian ;
Chen, Zhihong ;
Rajendran, Vani ;
Scherr, Heather ;
Lackey, Melinda ;
Bolduc, Clare ;
Bergmann, Andreas .
DEVELOPMENT, 2008, 135 (01) :43-52
[35]   IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis [J].
Maeda, S ;
Kamata, H ;
Luo, JL ;
Leffert, H ;
Karin, M .
CELL, 2005, 121 (07) :977-990
[36]   puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila [J].
Martín-Blanco, E ;
Gampel, A ;
Ring, J ;
Virdee, K ;
Kirov, N ;
Tolkovsky, AM ;
Martinez-Arias, A .
GENES & DEVELOPMENT, 1998, 12 (04) :557-570
[37]   Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis [J].
McEwen, DG ;
Peifer, M .
DEVELOPMENT, 2005, 132 (17) :3935-3946
[38]  
McEwen DG, 2000, DEVELOPMENT, V127, P3607
[39]   Cell cycling and patterned cell proliferation in the Drosophila wing during metamorphosis [J].
Milan, M ;
Campuzano, S ;
GarciaBellido, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11687-11692
[40]   Developmental parameters of cell death in the wing disc of Drosophila [J].
Milan, M ;
Campuzano, S ;
GarciaBellido, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (11) :5691-5696