An approach to a carbocyclic analogue of cyclic adenosine 5'-diphosphate ribose. The synthesis and bisphosphorylation of N-1-[(1S,3R)-3-(hydroxymethyl)cyclopent-1-yl]inosine.

被引：14

作者：

Fortt, SM ^{[1
]}

Potter, BVL ^{[1
]}

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,DEPT MED CHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(97)01175-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of N-1-[(1S, 3R)-3-(hydroxymethyl)cyclopent-1-yl]inosine (11) via a cyclocondensation route is reported. Regioselective bisphosphorylation of the primary 5'-hydroxyl groups leads to a carbocyclic, inosine analogue of seco adenosine 5'-diphosphate ribose (3). (C) 1997 Elsevier Science Ltd.

引用

页码：5371 / 5374

页数：4

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