A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats

被引：114

作者：

Zhang, Ning ^{[1
]}

Wang, Shilei ^{[1
]}

Li, Yu ^{[1
]}

Che, Lei ^{[1
]}

Zhao, Qin ^{[1
]}

机构：

[1] Qingdao Univ, Coll Med, Affiliated Hosp, Dept Anesthesiol, Qingdao 266003, Shandong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2013年 / 535卷

基金：

中国国家自然科学基金;

关键词：

Cerebral ischemia/reperfusion injury; Mitochondrial fission; Apoptosis; Protection; MITOCHONDRIAL FISSION; MAMMALIAN-CELLS; CYTOCHROME-C; DYNAMICS; MORPHOLOGY; DIVISION;

D O I：

10.1016/j.neulet.2012.12.049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Mitochondrial division inhibitor (mdivi-1) is a derivative of quinazolinone that acts as a selective inhibitor of a mitochondrial fission protein Drp1. A previous study demonstrated that as a selective inhibitor of Drp1, mdivi-1 has a protective effect in an experimental model of heart ischemia/reperfusion injury. In this study, we investigated the protective effects of mdivi-1 on cerebral ischemia/reperfusion injury in a middle cerebral artery occlusion mouse model. We found that mdivi-1 (1.2 mg/kg) significantly reduced cerebral damage induced by ischemia/reperfusion. This neuroprotective effect was dose-dependent. Mdivi-1 treatment blocked apoptotic cell death in cerebral ischemia/reperfusion injury, and significantly decreased the expression of Drp1 and Cytochrome C. These results suggest that mdivi-1 exerts neuroprotective effects against nerve injury after cerebral ischemia/reperfusion, and the underlying mechanism may be through the prevention of Cytochrome C release and suppression of the mitochondrial apoptosis pathway. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：104 / 109

页数：6

共 26 条

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