Direct carbon-carbon bond formation from alcohols and active methylenes, alkoxyketones, or indoles catalyzed by indium trichloride

被引：326

作者：

Yasuda, M

Somyo, T

Baba, A

机构：

[1] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Handai Frontier Res Ctr, Grad Sch Engn, Suita, Osaka 5650871, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 05期

关键词：

alcohols; C-C coupling; indium; synthetic methods;

D O I：

10.1002/anie.200503263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The unsalted variety: The direct coupling reaction of alcohols with active methylenes, alkoxyketones, or indoles catalyzed by InCl3 proceeds without the formation of metal salts (see scheme). As H2O is the only by-product of this system, the alkylated products are easily isolated in pure form, and the reaction is suitable for large-scale synthesis. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：793 / 796

页数：4

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