Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages

被引：163

作者：

Casero, David ^{[1
]}

Sandoval, Salemiz ^{[1
]}

Seet, Christopher S. ^{[2
]}

Scholes, Jessica ^{[3
]}

Zhu, Yuhua ^{[1
]}

Ha, Vi Luan ^{[4
]}

Luong, Annie ^{[4
]}

Parekh, Chintan ^{[4
,5
]}

Crooks, Gay M. ^{[1
,3
,6
,7
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA USA

[4] Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Los Angeles, CA 90027 USA

[5] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

DENDRITIC CELLS; EXPRESSION; EVOLUTION; PATTERNS;

D O I：

10.1038/ni.3299

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest stages of B lymphoid and T lymphoid specification. Over 3,000 genes encoding previously unknown long non-coding RNAs (IncRNAs) were revealed through the analysis of these rare populations. Lymphoid commitment was characterized by IncRNA expression patterns that were highly stage specific and were more lineage specific than those of protein-coding genes. Protein-coding genes co-expressed with neighboring IncRNA genes showed enrichment for ontologies related to lymphoid differentiation. The exquisite cell-type specificity of global IncRNA expression patterns independently revealed new developmental relationships among the earliest progenitor cells in the human bone marrow and thymus.

引用

页码：1282 / 1291

页数：10

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