Persistent and aggressive bacteria in the lungs of cystic fibrosis children

被引:64
作者
Hart, CA [1 ]
Winstanley, C [1 ]
机构
[1] Univ Liverpool, Dept Med Microbiol & Genitourinary Med, Liverpool L69 3GA, Merseyside, England
关键词
D O I
10.1093/bmb/61.1.81
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There have been enormous improvements in life expectancy of patients with cystic fibrosis, especially with improved nutrition and better understanding of the basic cellular defects. However, infection in particular with Pseudomonas aeruginosa and Burkholderia cepacia, has the greatest effect in decreasing life expectancy. Although infections can be prevented by rigorous infection control procedures, early aggressive antimicrobial chemotherapy and established infection managed by antibiotics, they are not completely effective. A greater understanding of how the bacteria evade the host defences and produce infection is needed.
引用
收藏
页码:81 / 96
页数:16
相关论文
共 117 条
[1]  
ARMSTRONG DS, 2000, PEDIATR PULM, V20, P285
[2]   Burkholderia cepacia is resistant to the antimicrobial activity of airway epithelial cells [J].
Baird, RM ;
Brown, H ;
Smith, AW ;
Watson, ML .
IMMUNOPHARMACOLOGY, 1999, 44 (03) :267-272
[3]   Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model [J].
Bals, R ;
Weiner, DJ ;
Meegalla, RL ;
Wilson, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (08) :1113-1117
[4]   The innate immune system in cystic fibrosis lung disease [J].
Bals, R ;
Weiner, DJ ;
Wilson, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (03) :303-307
[5]   DEFECTIVE ACIDIFICATION OF INTRACELLULAR ORGANELLES IN CYSTIC-FIBROSIS [J].
BARASCH, J ;
KISS, B ;
PRINCE, A ;
SAIMAN, L ;
GRUENERT, D ;
ALAWQATI, Q .
NATURE, 1991, 352 (6330) :70-73
[6]   Outbreak of subclinical mastitis in a flock of dairy sheep associated with Burkholderia cepacia complex infection [J].
Berriatua, E ;
Ziluaga, I ;
Miguel-Virto, C ;
Uribarren, P ;
Juste, R ;
Laevens, S ;
Vandamme, P ;
Govan, JRW .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (03) :990-994
[7]   Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis [J].
Burns, JL ;
Gibson, RL ;
McNamara, S ;
Yim, D ;
Emerson, J ;
Rosenfeld, M ;
Hiatt, P ;
McCcoy, K ;
Castile, R ;
Smith, AL ;
Ramsey, BW .
JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (03) :444-452
[8]   PSEUDOMONAS-AERUGINOSA OUTER-MEMBRANE ADHESINS FOR HUMAN RESPIRATORY MUCUS GLYCOPROTEINS [J].
CARNOY, C ;
SCHARFMAN, A ;
VANBRUSSEL, E ;
LAMBLIN, G ;
RAMPHAL, R ;
ROUSSEL, P .
INFECTION AND IMMUNITY, 1994, 62 (05) :1896-1900
[9]  
*CF TRUST, 2000, REP CF TRUSTS CONTRO, P1
[10]   COMPARISON OF PHYSICOCHEMICAL PROPERTIES OF PURIFIED MUCUS GLYCOPROTEINS ISOLATED FROM RESPIRATORY SECRETIONS OF CYSTIC-FIBROSIS AND ASTHMATIC-PATIENTS [J].
CHACE, KV ;
FLUX, M ;
SACHDEV, GP .
BIOCHEMISTRY, 1985, 24 (25) :7334-7341