Regulatory Role of G Protein-Coupled Estrogen Receptor for Vascular Function and Obesity

被引：306

作者：

Haas, Elvira ^{[1
]}

Bhattacharya, Indranil ^{[1
]}

Brailoiu, Eugen ^{[3
]}

Damjanovic, Marlen ^{[1
]}

Brailoiu, G. Cristina ^{[3
]}

Gao, Xin ^{[3
]}

Mueller-Guerre, Laurence ^{[1
]}

Marjon, Nicole A. ^{[4
]}

Gut, Andre ^{[1
]}

Minotti, Roberta ^{[1
]}

Meyer, Matthias R. ^{[1
]}

Amann, Kerstin ^{[6
]}

Ammann, Emerita ^{[1
]}

Perez-Dominguez, Ana ^{[1
]}

Genoni, Michele ^{[2
,7
]}

Clegg, Deborah J. ^{[8
]}

Dun, Nae J. ^{[3
]}

Resta, Thomas C. ^{[4
]}

Prossnitz, Eric R. ^{[4
,5
]}

Barton, Matthias ^{[1
]}

机构：

[1] Univ Spital Zurich, Klin & Poliklin Innere Med, Dept Innere Med, CH-8091 Zurich, Switzerland

[2] Univ Spital Zurich, Klin Herz & Gefasschirurg, CH-8091 Zurich, Switzerland

[3] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19122 USA

[4] Univ New Mexico, Hlth Sci Ctr, Dept Cell Biol & Physiol, Albuquerque, NM 87131 USA

[5] Univ New Mexico, Hlth Sci Ctr, Ctr Canc, Albuquerque, NM 87131 USA

[6] Univ Klinikum Erlangen, Inst Pathol, Erlangen, Germany

[7] Stadtspital Triemli, Klin Herzchirurg, Zurich, Switzerland

[8] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA

来源：

CIRCULATION RESEARCH | 2009年 / 104卷 / 03期

关键词：

IN-VITRO; 17-BETA-ESTRADIOL; BETA; ARTERIES; GPR30; ALPHA; ATHEROSCLEROSIS;

D O I：

10.1161/CIRCRESAHA.108.190892

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity. © 2009 American Heart Association.

引用

页码：288 / 291

页数：4

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