Immunosuppressants in cancer prevention and therapy

被引：47

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期

关键词：

cancer; geroconversion; immunosuppression; inflammation; mTOR; rapalog; rapamycin; senescence; EXTENDS LIFE-SPAN; RENAL-TRANSPLANT RECIPIENTS; EPSTEIN-BARR-VIRUS; SIROLIMUS-BASED IMMUNOSUPPRESSION; INDUCED INSULIN-RESISTANCE; TRANSGENIC MOUSE MODEL; AGE-RELATED DISEASES; MAMMALIAN TARGET; CELL SENESCENCE; MTOR-INHIBITOR;

D O I：

10.4161/onci.26961

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Rapalogs such as rapamycin (sirolimus), everolimus, temserolimus, and deforolimus are indicated for the treatment of some malignancies. Rapamycin is the most effective cancer-preventive agent currently known, at least in mice, dramatically delaying carcinogenesis in both normal and cancer-prone murine strains. In addition, rapamycin and everolimus decrease the risk of cancer in patients receiving these drugs in the context of immunosuppressive regimens. In general, the main concern about the use of immunosuppressants in humans is an increased risk of cancer. Given that rapalogs are useful in cancer prevention and therapy, should they be viewed as immunosuppressants or immunostimulators? Or should we reconsider the role of immunity in cancer altogether? In addition to its anti-viral, anti-inflammatory, anti-angiogenic and anti-proliferative effects, rapamycin operates as a gerosuppressant, meaning that it inhibits the cellular conversion to a senescent state (the so-called geroconversion), a fundamental process involved in aging and age-related pathologies including cancer.

引用

页码：1 / 8

页数：8

共 197 条

[1]

Alain T, 2012, ONCOTARGET, V3, P1491

[2]

Lower Malignancy Rates in Renal Allograft Recipients Converted to Sirolimus-Based, Calcineurin Inhibitor-Free Immunotherapy: 24-Month Results From the CONVERT Trial [J].

Alberu, Josefina ;

Pascoe, Michael D. ;

Campistol, Josep M. ;

Schena, Francesco P. ;

del Carmen Rial, Maria ;

Polinsky, Martin ;

Neylan, John F. ;

Korth-Bradley, Joan ;

Goldberg-Alberts, Robert ;

Maller, Eric S. .

TRANSPLANTATION, 2011, 92 (03) :303-310

[3]

Targeting mTOR for the treatment of AML. New agents and new directions. [J].

Altman, Jessica K. ;

Sassano, Antonella ;

Platanias, Leonidas C. .

ONCOTARGET, 2011, 2 (06) :510-517

[4]

Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice [J].

Amiel, Eyal ;

Everts, Bart ;

Freitas, Tori C. ;

King, Irah L. ;

Curtis, Jonathan D. ;

Pearce, Erika L. ;

Pearce, Edward J. .

JOURNAL OF IMMUNOLOGY, 2012, 189 (05) :2151-2158

[5]

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice [J].

Anisimov, Vladimir N. ;

Zabezhinski, Mark A. ;

Popovich, Irina G. ;

Piskunova, Tatiana S. ;

Semenchenko, Anna V. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Rosenfeld, Svetlana V. ;

Blagosklonny, Mikhail V. .

CELL CYCLE, 2011, 10 (24) :4230-4236

[6]

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice [J].

Anisimov, Vladimir N. ;

Berstein, Lev M. ;

Popovich, Irina G. ;

Zabezhinski, Mark A. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Semenchenko, Anna V. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Kovalenko, Irina G. ;

Poroshina, Tatiana E. .

AGING-US, 2011, 3 (02) :148-157

[7]

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice [J].

Anisimov, Vladimir N. ;

Piskunova, Tatiana S. ;

Popovich, Irina G. ;

Zabezhinski, Mark A. ;

Tyndyk, Margarita L. ;

Egormin, Peter A. ;

Yurova, Maria N. ;

Rosenfeld, Svetlana V. ;

Semenchenko, Anna V. ;

Kovalenko, Irina G. ;

Poroshina, Tatiana E. ;

Berstein, Lev M. .

AGING-US, 2010, 2 (12) :945-958

[8]

Metformin for aging and cancer prevention [J].

Anisimov, Vladimir N. .

AGING-US, 2010, 2 (11) :760-774

[9]

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice [J].

Anisimov, Vladimir N. ;

Zabezhinski, Mark A. ;

Popovich, Irina G. ;

Piskunova, Tatiana S. ;

Semenchenko, Anna V. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Antoch, Marina P. ;

Blagosklonny, Mikhail V. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) :2092-2097

[10]

Metformin extends life span of HeR-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo [J].

Anisimov, Vladimir N. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Popovich, Irina G. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Zabezhinski, Mark A. ;

Anikin, Ivan V. ;

Karkach, Arseniy S. ;

Romanyukha, Alexey A. .

CELL CYCLE, 2010, 9 (01) :188-197

← 1 2 3 4 5 6 7 8 9 10 →