Human tumor antigens recognized by T cells

被引：185

作者：

Robbins, PF

Kawakami, Y

机构：

[1] Surgery Branch, Division of Clinical Sciences, National Institutes of Health, Bethesda, MD 20892-1502

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(96)80078-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of tumor-reactive T cells to mediate in vivo tumor regression has been demonstrated in murine tumor models and by the clinical responses to adoptive immunotherapy with tumor-infiltrating lymphocytes isolated from human melanomas. Investigations carried out in the past several years have resulted in the isolation of a number of the genes encoding antigens recognized by melanoma-reactive T cells. The ability of these products to serve as tumor regression antigens has now begun to be evaluated in clinical vaccine trials.

引用

收藏

页码：628 / 636

页数：9

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