Identification of the sigB operon in Staphylococcus epidermidis:: Construction and characterization of a sigB deletion mutant

被引：23

作者：

Kies, S ^{[1
]}

Otto, M ^{[1
]}

Vuong, C ^{[1
]}

Götz, F ^{[1
]}

机构：

[1] Univ Tubingen, D-72076 Tubingen, Germany

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 12期

关键词：

D O I：

10.1128/IAI.69.12.7933-7936.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of the alternative sigma factor sigma (B) in Staphylococcus epidermidis was investigated by the construction, complementation, and characterization of a sigB deletion mutant. Electrophoretic analyses confirmed a profound influence of sigma (B) on the expression of exoproteins and cytoplasmic proteins. Detailed investigation revealed reduced lipase and enhanced protease activity in the sigma (B) mutant. Furthermore, no significant influence of sigma (B) on heterologous biofilm formation or on the activity of the global regulator agr was detected.

引用

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页码：7933 / 7936

页数：4

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