Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase

被引：54

作者：

Collman, James P. ^{[1
]}

Decreau, Richard A. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 41期

关键词：

D O I：

10.1039/b808070b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A functional analog of the active site in the respiratory enzyme, cytochrome c oxidase (CcO) reproduces every feature in CcO's active site: a myoglobin-like heme (heme a3), a distal tridentate imidazole copper complex (Cu-B), a phenol (Tyr244), and a proximal imidazole. When covalently attached to a liquid-crystalline SAM film on an Au electrode, this functional model continuously catalyzes the selective four-electron reduction of dioxygen at physiological potential and pH, under rate-limiting electron flux (as occurs in CcO).

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收藏

页码：5065 / 5076

页数：12

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