Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase

被引：54

作者：

Collman, James P. ^{[1
]}

Decreau, Richard A. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 41期

关键词：

D O I：

10.1039/b808070b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A functional analog of the active site in the respiratory enzyme, cytochrome c oxidase (CcO) reproduces every feature in CcO's active site: a myoglobin-like heme (heme a3), a distal tridentate imidazole copper complex (Cu-B), a phenol (Tyr244), and a proximal imidazole. When covalently attached to a liquid-crystalline SAM film on an Au electrode, this functional model continuously catalyzes the selective four-electron reduction of dioxygen at physiological potential and pH, under rate-limiting electron flux (as occurs in CcO).

引用

收藏

页码：5065 / 5076

页数：12

相关论文

共 103 条

[31] Novel protecting strategy for the synthesis of porphyrins with different distal and proximal superstructures [J].

Collman, JP ;

Bröring, M ;

Fu, L ;

Rapta, M ;

Schwenninger, R ;

Straumanis, A .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) :8082-8083

[32] Imidazole acid chlorides:: Preparation and application in the syntheses of biomimetic heme models [J].

Collman, JP ;

Bröring, M ;

Fu, L ;

Rapta, M ;

Schwenninger, R .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) :8084-8085

[33] Close structural analogues of the cytochrome c oxidase Fea3/CuB center show clean 4e- electroreduction of O2 to H2O at physiological pH [J].

Collman, JP ;

Rapta, M ;

Bröring, M ;

Raptova, L ;

Schwenninger, R ;

Boitrel, B ;

Fu, L ;

L'Her, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (06) :1387-1388

[34] PICKET-FENCE PORPHYRINS - SYNTHETIC MODELS FOR OXYGEN BINDING HEMOPROTEINS [J].

COLLMAN, JP ;

GAGNE, RR ;

REED, CA ;

HALBERT, TR ;

LANG, G ;

ROBINSON, WT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1427-1439

[35] Synthetic models for hemoglobin and myoglobin [J].

Collman, JP ;

Fu, L .

ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (06) :455-463

[36] Elucidating the coordination chemistry and mechanism of biological nitrogen fixation [J].

Dance, Ian .

CHEMISTRY-AN ASIAN JOURNAL, 2007, 2 (08) :936-946

[37] The post-translational modification cytochrome c oxidase is required to establish a functional environment of the catalytic site [J].

Das, TK ;

Pecoraro, C ;

Tomson, FL ;

Gennis, RB ;

Rousseau, DL .

BIOCHEMISTRY, 1998, 37 (41) :14471-14476

[38] Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry [J].

Decreau, Richard A. ;

Collman, James P. ;

Yang, Ying ;

Yan, Yilong ;

Devaraj, Neal K. .

JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (08) :2794-2802

[39] Copper catalyzed azide-alkyne cycloadditions on solid surfaces: Applications and future directions [J].

Devaraj, Neal K. ;

Collman, James P. .

QSAR & COMBINATORIAL SCIENCE, 2007, 26 (11-12) :1253-1260

[40] Rate of interfacial electron transfer through the 1,2,3-triazole linkage [J].

Devaraj, Neal K. ;

Decreau, Richard A. ;

Ebina, Wataru ;

Collman, James P. ;

Chidsey, Christopher E. D. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (32) :15955-15962

← 1 2 3 4 5 6 7 8 9 10 →