Cytotoxic 5-Hydroxyindole Alkaloids from the Marine Sponge Scalarispongia sp.

被引：22

作者：

Lee, Yeon-Ju ^{[1
]}

Lee, Dong-Geun ^{[1
]}

Rho, Hyun Soo ^{[1
]}

Krasokhin, Vladimir B. ^{[2
]}

Shin, Hee Jae ^{[1
]}

Lee, Jong Seok ^{[1
]}

Lee, Hyi-Seung ^{[1
]}

机构：

[1] Korea Ocean Res & Dev Inst, Ansan 426744, South Korea

[2] RAS, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 06期

关键词：

ANNELATED INDOLE SERIES; NATURAL-PRODUCTS; DRUG LEADS; BISINDOLE ALKALOIDS; SPONGOSORITES SP; A-C; INHIBITORS; HYRTIOS; BIS; DERIVATIVES;

D O I：

10.1002/jhet.1599

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new 5-hydroxyindole alkaloids (1, 2, 3) along with seven known analogs (4, 5, 6, 7, 8, 9, 10) were isolated from a Dokdo marine sponge Scalarispongia sp. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate (1), a mono-indole analog of hyrtinadine A (2), and a symmetrical bis-indole with pyridine linker (3). The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis-indole structure is a requirement for cytotoxicity.

引用

页码：1400 / 1404

页数：5

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