Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.

被引：181

作者：

Bao, BQ

Sun, QS

Yao, XS

Hong, JK

Lee, CO

Sim, CJ

Im, KS

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

[3] Korea Basic Sci Inst, Seoul 136701, South Korea

[4] Korea Res Inst Chem Technol, Taejon 305343, South Korea

[5] Hannam Univ, Dept Biol, Taejon 306791, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 05期

关键词：

D O I：

10.1021/np049577a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new bisindole alkaloids of the hamacanthin class (1-3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole alkaloids (4, 5, 7-11) from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR, MS, and IR spectroscopic analyses. Configurations of compounds 1-4 were derived from H-1 NMR data and optical rotation. Compounds 1, 4, 5, and 11 showed moderate to significant cytotoxicity against five human tumor cell lines, and compounds 1-5 showed weak antibacterial activity against clinically isolated methicillin-resistant strains.

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页码：711 / 715

页数：5

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