Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch?

被引：23

作者：

Ilagan, Ma Xenia G. ^{[1
]}

Kopan, Raphael ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

CANCER CELL | 2013年 / 23卷 / 03期

关键词：

MUTATIONS;

D O I：

10.1016/j.ccr.2013.02.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

NOTCH1, which is frequently mutated in T cell acute lymphoblastic leukemia, has been an elusive therapeutic target. In this issue of Cancer Cell, Roti and colleagues demonstrate that inhibiting SERCA calcium pumps preferentially impairs the maturation of the most common class of oncogenic Notch1 mutants, thus uncovering a potential therapeutic avenue.

引用

页码：267 / 269

页数：3

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