Highly diastereoselective asymmetric aldol reactions of chiral Ni(II)-complex of glycine with alkyl trifluoromethyl ketones

被引：93

作者：

Soloshonok, VA ^{[1
]}

Avilov, DV ^{[1
]}

Kukhar, VP ^{[1
]}

机构：

[1] UKRAINIAN ACAD SCI,INST BIOORGAN CHEM & PETROCHEM,KIEV 253160,UKRAINE

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期

关键词：

D O I：

10.1016/0957-4166(96)00177-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric aldol reactions between prochiral trifluoromethyl ketones and Ni(II)-complex of monochiral Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone (BBP) are described. General stereodirecting features of the trifluoromethyl group controlling (2S,3S)-absolute configuration (90-98 %de) of the resultant amino acids is demonstrated. New set of reaction conditions allowing preparative synthesis of diastereo, and enantiomerically pure (2S,3S)-3-trifluoromethyl-3-substituted serines of biomedicinal interest is presented. (C) 1996 Elsevier Science Ltd

引用

页码：1547 / 1550

页数：4

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