A Novel Bifunctional Sulfonamide Primary Amine-Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins

被引：72

作者：

Xue, Fei ^{[1
]}

Zhang, Shilei ^{[1
]}

Duan, Wenhu ^{[1
,2
]}

Wang, Wei ^{[1
,3
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 14-15期

关键词：

conjugate addition; ketones; nitroolefins; organocatalysis; sulfonamide primary amine;

D O I：

10.1002/adsc.200800445

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The enantioselective conjugate addition of a variety of ketones to nitroolefins has been developed. The process is efficiently catalyzed by a novel bifunctional sulfonamide primary amine in good yields and with good levels of enantioselectivity.

引用

页码：2194 / 2198

页数：5

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