Nitric oxide photocaging platinum nanoparticles with anticancer potential

被引:39
作者
Barone, Mariarita [1 ]
Sciortino, Maria T. [2 ]
Zaccaria, Daniela [2 ]
Mazzaglia, Antonino [3 ]
Sortino, Salvatore [1 ]
机构
[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[2] Univ Messina, Dipartimento Sci Microbiol Genet & Mol, I-98166 Messina, Italy
[3] Univ Messina, ISMN CNR, Dipartimento Chim Inorgan Analit & Chim Fis, I-98166 Messina, Italy
关键词
D O I
10.1039/b809121h
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
In this contribution we report the design, fabrication and properties of hydrosoluble platinum nanoparticles decorated with a nitric oxide (NO) caging compound. Direct monitoring of NO through an ultrasensitive NO electrode demonstrate that the nanoparticles are stable in the dark but supply NO at nanomolar levels exclusively upon light excitation. The biocompatibility of these nanohybrid systems and their potential in photoactivated anticancer therapy have been explored by in vitro experiments using tumor cell lines. Overall these nanoparticles meet a combination of ideal prerequisites in the context of biomedical applications. Indeed, they associate small sizes, good water solubility and thermal stability under physiological conditions with excellent biocompatibility and appreciable tumor cell mortality upon irradiation with visible light. All these features make our photoactivable nanoparticles very appealing point sources of NO from the viewpoint of practical application in the emerging field of nanomedicine.
引用
收藏
页码:5531 / 5536
页数:6
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