Signaling by death receptors in the nervous system

被引：81

作者：

Haase, Georg ^{[3
]}

Pettmann, Brigitte ^{[4
]}

Raoul, Cedric ^{[4
]}

Henderson, Christopher E. ^{[1
,2
]}

机构：

[1] Columbia Univ, Ctr Motor Neuron Biol & Dis, Dept Pathol, New York, NY 10032 USA

[2] Columbia Univ, Ctr Motor Neuron Biol & Dis, Dept Neurol & Neurosci, New York, NY 10032 USA

[3] CNRS, IBDML, UMR 6216, Marseille 09, France

[4] INMED, Mediterranean Inst Neurobiol, INSERM Avenir, Marseille 09, France

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2008年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.conb.2008.07.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell death plays an important role both in shaping the developing nervous system and in neurological disease and traumatic injury. In spite of their name, death receptors can trigger either cell death or survival and growth. Recent studies implicate five death receptors - Fas/CD95, TNFR1 (tumor necrosis factor receptor-1), p75(NTR) (p75 neurotrophin receptor), DR4, and DR5 (death receptors-4 and -5) - in different aspects of neural development or degeneration. Their roles may be neuroprotective in models of Parkinson's disease, or pro-apoptotic in ALS and stroke. Such different outcomes probably reflect the diversity of transcriptional and post-translational signaling pathways downstream of death receptors in neurons and glia.

引用

页码：284 / 291

页数：8

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