Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging

被引：341

作者：

Fan, Wenpei ^{[1
]}

Shen, Bo ^{[2
]}

Bu, Wenbo ^{[1
]}

Chen, Feng ^{[1
]}

Zhao, Kuaile ^{[3
]}

Zhang, Shengjian ^{[3
]}

Zhou, Liangping ^{[3
]}

Peng, Weijun ^{[3
]}

Xiao, Qingfeng ^{[1
]}

Xing, Huaiyong ^{[1
]}

Liu, Jianan ^{[1
]}

Ni, Dalong ^{[1
]}

He, Qianjun ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 17期

基金：

中国国家自然科学基金;

关键词：

VIVO PHOTODYNAMIC THERAPY; UP-CONVERSION; X-RAY; SILICA NANORATTLE; CONCURRENT CHEMOTHERAPY; RADIATION-THERAPY; CANCER; NANOPARTICLES; DELIVERY; SHELL;

D O I：

10.1021/ja312225b

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.

引用

页码：6494 / 6503

页数：10

共 49 条

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