Total synthesis of lamellarins D, L, and N

被引：110

作者：

Fujikawa, N

Ohta, T

Yamaguchi, T

Fukuda, T

Ishibashi, F

Iwao, M

机构：

[1] Nagasaki Univ, Fac Engn, Dept Appl Chem, Nagasaki 8528521, Japan

[2] Nagasaki Univ, Grad Sch Sci & Technol, Nagasaki 8528521, Japan

[3] Nagasaki Univ, Fac Fisheries, Div Marine Life Sci & Biochem, Nagoya, Aichi 8528521, Japan

来源：

TETRAHEDRON | 2006年 / 62卷 / 04期

关键词：

total synthesis; lamellarin; Hinsberg reaction; Suzuki-Miyaura coupling;

D O I：

10.1016/j.tet.2005.10.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of cytotoxic marine alkaloids, lamellarins D, L, and N, has been achieved by using Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki-Miyaura coupling of the 3,4-dihydroxypyrrole bistriflate 6 as the key reactions. The total yields of lamellarins D, L, and N from the common intermediate 6 are 54, 58, and 50%, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：594 / 604

页数：11

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