Clinical metabolomics paves the way towards future healthcare strategies

被引：74

作者：

Collino, Sebastiano ^{[1
]}

Martin, Francois-Pierre J. ^{[1
]}

Rezzi, Serge ^{[1
]}

机构：

[1] Nestec Ltd, Nestle Res Ctr, BioAnalyt Sci Metabol & Biomarkers, CH-1000 Lausanne 26, Switzerland

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2013年 / 75卷 / 03期

关键词：

biomarkers; clinical metabolomics; gut microflora; INFLAMMATORY-BOWEL-DISEASE; NUCLEAR-MAGNETIC-RESONANCE; FATTY LIVER-DISEASE; NMR-SPECTROSCOPY; GUT MICROFLORA; METABONOMICS APPROACH; ULCERATIVE-COLITIS; SYSTEMS BIOLOGY; MOUSE MODEL; BIOMARKERS;

D O I：

10.1111/j.1365-2125.2012.04216.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammalian systems with regard to disease aetiology, diagnostic stratification and, potentially, mechanism of action of therapeutic solutions. A key feature of metabolomics lies in its ability to underpin the complex metabolic interactions of the host with its commensal microbial partners providing a new way to define individual and population phenotypes. This review aims at describing recent applications of metabolomics in clinical fields with insight into diseases, diagnostics/monitoring and improvement of homeostatic metabolic regulation.

引用

页码：619 / 629

页数：11

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