Clipping or Extracting: Two Ways to Membrane Protein Degradation

被引：71

作者：

Avci, Doenem ^{[1
]}

Lemberg, Marius K. ^{[1
]}

机构：

[1] Univ Heidelberg ZMBH, DKFZ ZMBH Allianz, Zentrum Mol Biol, D-69120 Heidelberg, Germany

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 10期

关键词：

SIGNAL PEPTIDE PEPTIDASE; HMG-COA REDUCTASE; REGULATED INTRAMEMBRANE PROTEOLYSIS; AMYLOID PRECURSOR PROTEIN; AAA-ATPASE; ENDOPLASMIC-RETICULUM; GAMMA-SECRETASE; QUALITY-CONTROL; UBIQUITIN-LIGASE; CLEAVAGE;

D O I：

10.1016/j.tcb.2015.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein degradation is a fundamentally important process that allows cells to recognize and remove damaged protein species and to regulate protein abundance according to functional need. A fundamental challenge is to understand how membrane proteins are recognized and removed from cellular organelles. While most of our understanding of this mechanism comes from studies on p97/Cdc48-mediated protein dislocation along the endoplasmic reticulum (ER)associated degradation (ERAD) pathway, recent studies have revealed intramembrane proteolysis to be an additional mechanism that can extract transmembrane segments. Here, we review these two principles in membrane protein degradation and discuss how intramembrane proteolysis, which introduces an irreversible step in protein dislocation, is used to drive regulated protein turnover.

引用

页码：611 / 622

页数：12

共 107 条

[11] Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins [J].

Chen, Yu-Chan ;

Umanah, George K. E. ;

Dephoure, Noah ;

Andrabi, Shaida A. ;

Gygi, Steven P. ;

Dawson, Ted M. ;

Dawson, Valina L. ;

Rutter, Jared .

EMBO JOURNAL, 2014, 33 (14) :1548-1564

[12] Cleaning up in the endoplasmic reticulum: ubiquitin in charge [J].

Christianson, John C. ;

Ye, Yihong .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (04) :325-335

[13] Defining human ERAD networks through an integrative mapping strategy [J].

Christianson, John C. ;

Olzmann, James A. ;

Shaler, Thomas A. ;

Sowa, Mathew E. ;

Bennett, Eric J. ;

Richter, Caleb M. ;

Tyler, Ryan E. ;

Greenblatt, Ethan J. ;

Harper, J. Wade ;

Kopito, Ron R. .

NATURE CELL BIOLOGY, 2012, 14 (01) :93-U176

[14] Mechanisms of Integral Membrane Protein Insertion and Folding [J].

Cymer, Florian ;

von Heijne, Gunnar ;

White, Stephen H. .

JOURNAL OF MOLECULAR BIOLOGY, 2015, 427 (05) :999-1022

[15] Improved structures of full-length p97, an AAA ATPase: Implications for mechanisms of nucleotide-dependent conformational change [J].

Davies, Jason M. ;

Brunger, Axel T. ;

Weis, William I. .

STRUCTURE, 2008, 16 (05) :715-726

[16] Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex [J].

De Strooper, B .

NEURON, 2003, 38 (01) :9-12

[17] A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain [J].

De Strooper, B ;

Annaert, W ;

Cupers, P ;

Saftig, P ;

Craessaerts, K ;

Mumm, JS ;

Schroeter, EH ;

Schrijvers, V ;

Wolfe, MS ;

Ray, WJ ;

Goate, A ;

Kopan, R .

NATURE, 1999, 398 (6727) :518-522

[18] Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [J].

De Strooper, B ;

Saftig, P ;

Craessaerts, K ;

Vanderstichele, H ;

Guhde, G ;

Annaert, W ;

Von Figura, K ;

Van Leuven, F .

NATURE, 1998, 391 (6665) :387-390

[19] Central pore residues mediate the p97/VCP activity required for ERAD [J].

DeLaBarre, Byron ;

Christianson, John C. ;

Kopito, Ron R. ;

Brunger, Axel T. .

MOLECULAR CELL, 2006, 22 (04) :451-462

[20] A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains [J].

Duggan, Stephen P. ;

Yan, Run ;

McCarthy, Justin V. .

FEBS LETTERS, 2015, 589 (09) :1001-1008

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