Molecular mechanisms of TNF-α-induced apoptosis in naive and memory T cell subsets

被引：25

作者：

Gupta, Sudhir ^{[1
]}

Gollapudi, Sastry ^{[1
]}

机构：

[1] Univ Calif Irvine, Div Basic & Clin Immunol, Irvine, CA 92697 USA

来源：

AUTOIMMUNITY REVIEWS | 2006年 / 5卷 / 04期

关键词：

death receptors; mitochondria; endoplasmic reticulum; calcium; aging;

D O I：

10.1016/j.autrev.2005.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Aging in humans is associated with progressive decline in T cell function, hyperimmunoglobulinemia, increased prevalence of autoantibodies and decline in naive CD8(+) T cells and accumulation of memory T cells, which appears to be oligoclonal and display feature of senescence, that is, decreased replication, short telomere length and resistance to apoptosis. Recently memory T cells have been further subdivided into central and effector memory T cells, based upon their migratory and homing properties. They are identified by a number of cell surface makers. In this brief review we will discuss molecular mechanisms of apoptosis in naive and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：264 / 268

页数：5

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